C2931
Sigma
Monoclonal Anti-Cytokeratin, pan antibody produced in mouse
clone C-11, ascites fluid
| Synonym: | Monoclonal Anti-Pan Cytokeratin |
Description
| Immunogen | keratin-enriched preparation from cultured human epidermoid carcinoma cell line A431. |
| Specificity | The antibody recognizes human cytokeratins 4, 5, 6, 8, 10, 13, and 18. A broad spectrum antibody that reacts with a wide variety of normal, reactive, and neoplastic epithelial tissues. This antibody may be used for staining cultured epithelial cell lines. |
Properties
| antibody form | ascites fluid |
| clone | C-11 (monoclonal) |
| contains | 15 mM sodium azide |
| species reactivity | bovine, frog, human, rat, kangaroo rat, mouse |
| application(s) | immunoblotting: suitable |
| immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable using protease-digested sections of human or animal tissues | |
| immunohistochemistry (frozen sections): suitable | |
| indirect immunofluorescence: 1:400 using protease-digested, formalin-fixed, paraffin-embedded sections of human or animal tissues | |
| isotype | IgG1 |
| Gene Information | human ... KRT13(3858), KRT18(3875), KRT4(3851), KRT5(3852), KRT6A(3868), KRT6B(3854), KRT8(3856) |
| rat ... Krt1-18(706059), Krt10(450225), Krt2-5(369017), Krt2-8(25626) | |
| mouse ... Krt10(16661), Krt13(16663), Krt18(16668), Krt4(16682), Krt5(110308), Krt6a(16687), Krt6b(16688), Krt8(16691) | |
| shipped in | dry ice |
| storage temp. | −20°C |
Safety
| WGK Germany | 3 |
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References
| reference | Rowning, B.A., et al., Establishment of the Dorso-ventral Axis in Xenopus Embryos Is Presaged by Early Asymmetries in β-Catenin That Are Modulated by the Wnt Signaling Pathway J. Cell Biol. 136, 1123-1136, (1997) Abstract |
| Cuffini, C., et al., Susceptibility of Prostate Epithelial Cells to Chlamydia muridarum Infection and Their Role in Innate Immunity by Recruitment of Intracellular Toll-Like Receptors 4 and 2 and MyD88 to the Inclusion Infect. Immun. 74, 6973-6981, (2006) Abstract | |
| Hasan, A., et al., Identification of cytokeratin 1 as a binding protein and presentation receptor for kininogens on endothelial cells Proc. Natl. Acad. Sci. U. S. A. 95, 3615-3620, (1998) Abstract | |
| Bartek, J., et al. J. Pathol. 164, 215, (1991) | |
| Bartkova, J., et al. Neoplasma 38, 439, (1991) | |
| Lane, E.B. and Alexander, C.M. Semin. Cancer Biol. 1, 165, (1990) |
